Osteoradionecrosis “PENTO” protocol results

Source: Systematic review of the use of pentoxifylline and tocopherol for the treatment of medication-related osteonecrosis of the jaw

Heifetz-Li, Jiean Joseph et al.

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Volume 128, Issue 5, 491 - 497.e2

An oral antiseptic swish and spit, such as chlorhexidine 15 mL swish and spit after meals and before bed may also be used.

Use of systemic antibiotics is of unproven efficacy.

Supplementation of vitamin D deficiency may be undertaken.

Repeated surgical debridement of dead tissue may be necessary.